ARHGEF18 Antibody, HRP conjugated

Size : 50 µg Clone Number: Aliases: 114 kDa Rho specific guanine nucleotide exchange factor antibody; 114 kDa Rho-specific guanine nucleotide exchange factor antibody; ARHGEF 18 antibody; Arhgef18 antibody; ARHGI_HUMAN antibody; KIAA0521 antibody; MGC15913 antibody; p114 Rho GEF antibody; p114-Rho-GEF antibody; p114RhoGEF antibody; Rho guanine nucleotide exchange factor 18 antibody; Rho specific guanine nucleotide exchange factor p114 antibody; Rho/Rac guanine nucleotide exchange factor (GEF) 18 antibody; Rho/Rac guanine nucleotide exchange factor 18 antibody; SA RhoGEF antibody; SA-RhoGEF antibody; Septin associated RhoGEF antibody; Septin-associated RhoGEF antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q6ZSZ5 Immunogen: Recombinant Human Rho guanine nucleotide exchange factor 18 protein (159-551AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA Background: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed: 22006950). Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: HRP Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: ARHGEF18 Research Areas: Signal transduction