Phospho-HCK (Tyr521) Antibody

Size : 100 µL Clone Number: Aliases: Bmk antibody; Hck 1 antibody; Hck antibody; HCK_HUMAN antibody; Hemopoietic cell kinase antibody; JTK9 antibody; p59-HCK/p60-HCK antibody; p59Hck antibody; p59HCK/p60HCK antibody; p61Hck antibody; Tyrosine protein kinase HCK antibody; Tyrosine-protein kinase HCK antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P08631 Immunogen: Peptide sequence around phosphorylation site of tyrosine 521(E-S-Q(p)-Y-Q) derived from Human HCK . Host: Rabbit Reactivity: Human, Mouse, Rat Tested Applications: ELISA, WB; WB: 1: 500-1: 1000 Background: The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization. Quintrell N., Mol. Cell. Biol. 7: 2267-2275(1987) [PubMed: 3496523]. Ziegler S.F.,Mol. Cell. Biol. 7: 2276-2285(1987) [PubMed: 3453117]. Ota T., Nat. Genet. 36: 40-45(2004) [PubMed: 14702039]. Clonality: Polyclonal Isotype: IgG Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: HCK Research Areas: Immunology;Signal transduction