Phospho-GAB2 (Ser623) Antibody

Size : 100 µL Clone Number: Aliases: GAB 2 antibody; Gab2 antibody; GAB2_HUMAN antibody; Grb 2 associated binder 2 antibody; GRB 2 associated binding protein 2 antibody; Grb2 associated binder 2 antibody; GRB2 associated binder 2 pp100 antibody; GRB2 associated binding protein 2 antibody; GRB2-associated binder 2 antibody; GRB2-associated-binding protein 2 antibody; Growth factor receptor bound protein 2 associated protein 2 antibody; Growth factor receptor bound protein 2-associated protein 2 antibody; KIAA0571 antibody; p97 antibody; PH domain containing adaptor molecule p97 antibody; pp100 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q9UQC2 Immunogen: Peptide sequence around phosphorylation site of Serine 623(P-S-S(p)-P-S) derived from Human Gab2 . Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, WB, IHC; WB: 1: 500-1: 1000, IHC: 1: 50-1: 100 Background: This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. Nishida K., Blood 93: 1809-1816(1999). Nagase T., DNA Res. 5: 31-39(1998). Taylor T.D., Nature 440: 497-500(2006). Clonality: Polyclonal Isotype: IgG Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: GAB2 Research Areas: Neuroscience?Cancer;Signal transduction