Phospho-FADD (Ser191) Antibody

Size : 100 µL Clone Number: Aliases: FADD antibody; FADD protein antibody; FADD_HUMAN antibody; Fas (TNFRSF6) associated via death domain antibody; Fas associated via death domain antibody; Fas associating death domain containing protein antibody; Fas associating protein antibody; Fas associating protein with death domain antibody; Fas TNFRSF6 associated via death domain antibody; FAS-associated death domain protein antibody; FAS-associating death domain-containing protein antibody; GIG 3 antibody; GIG3 antibody; Growth inhibiting gene 3 protein antibody; Growth-inhibiting gene 3 protein antibody; H sapiens mRNA for mediator of receptor induced toxicity antibody; Mediator of receptor induced toxicity antibody; MGC8528 antibody; MORT 1 antibody; MORT1 antibody; Protein FADD antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q13158 Immunogen: Peptide sequence around phosphorylation site of Serine191(R-S-G(p)-A-M) derived from Human FADD. Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, WB, IHC; WB: 1: 500-1: 1000, IHC: 1: 50-1: 100 Background: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. Sugano S., Nat. Genet. 36: 40-45(2004). Farmer A., Submitted (MAY-2003). Venter J.C., Submitted (JUL-2005). Clonality: Polyclonal Isotype: IgG Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: FADD Research Areas: Cancer;Cell biology