Phospho-HNRNPD (Ser83) Antibody

Size : 100 µL Clone Number: Aliases: ARE binding protein AUFI type A antibody; AU-rich element RNA-binding protein 1 antibody; AUF antibody; AUF1 antibody; AUF1A antibody; Heterogeneous nuclear ribonucleoprotein D0 antibody; hnRNP D antibody; hnRNP D0 antibody; Hnrnpd antibody; hnRNPD0 antibody; HNRPD antibody; HNRPD_HUMAN antibody; P37 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q14103 Immunogen: Peptide sequence around phosphorylation site of Serine 83(N-S-S(p)-P-R) derived from Human hnRPD . Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, WB, IHC, IF; WB: 1: 500-1: 1000, IHC: 1: 50-1: 100, IF: 1: 100-1: 200 Background: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Kajita Y., J. Biol. Chem. 270: 22167-22175(1995). Dempsey L.A., Genomics 49: 378-384(1998). Tolnay M., Biochem. J. 338: 417-425(1999). Grosset C., Cell 103: 29-40(2000) Clonality: Polyclonal Isotype: IgG Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: HNRNPD Research Areas: Epigenetics and Nuclear Signaling