Phospho-CDC25B (Ser353) Antibody

Size : 100 µL Clone Number: Aliases: AI604853 antibody; Cdc 25B antibody; Cdc25b antibody; CDC25HU2 antibody; Cdc25m2 antibody; Cell division cycle 25 homolog B antibody; Cell division cycle 25B antibody; Cell division cycle 25B isoform 1 antibody; Cell division cycle 25B isoform 2 antibody; Cell division cycle 25B isoform 3 antibody; Cell division cycle 25B isoform 4 antibody; Cell division cycle 25B isoform 5 antibody; Dual specificity phosphatase Cdc25B antibody; EC 3.1.3.48 antibody; M phase inducer phosphatase 2 antibody; M-phase inducer phosphatase 2 antibody; MPIP2_HUMAN antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P30305 Immunogen: Peptide sequence around phosphorylation site of serine 353(R-R-S(p)-V-T) derived from Human CDC25B . Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB; WB: 1: 500-1: 1000 Background: Cdc25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. Reboutier D, et al. (2012) J Cell Biol 197, 19-26 Lobjois V, et al. (2011) Biochem Biophys Res Commun 410, 87-90 Feng C, et al. (2007) Biol Reprod 77, 560-8 Clonality: Polyclonal Isotype: IgG Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CDC25B Research Areas: Epigenetics and Nuclear Signaling;Cancer;Cell biology