Phospho-CBL (Tyr674) Antibody

Size : 100 µL Clone Number: Aliases: 4732447J05Rik antibody; C CBL antibody; Cas Br M (murine) ecotropic retroviral transforming sequence antibody; Casitas B lineage lymphoma proto oncogene antibody; Casitas B-lineage lymphoma proto-oncogene antibody; CBL 2 antibody; cbl antibody; CBL_HUMAN antibody; CBL2 antibody; E3 ubiquitin protein ligase CBL antibody; E3 ubiquitin-protein ligase CBL antibody; Oncogene CBL2 antibody; Proto oncogene c CBL antibody; Proto-oncogene c-CBL antibody; RGD1561386 antibody; RING finger protein 55 antibody; RNF55 antibody; Signal transduction protein CBL antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P22681 Immunogen: Peptide sequence around phosphorylation site of Tyrosine674 (A-I-Y(p)-S-L) derived from Human CBL. Host: Rabbit Reactivity: Human, Mouse, Rat Tested Applications: ELISA, WB; WB: 1: 500-1: 1000 Background: Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling. Fernandes MS, et al. (2010) J Biol Chem 285, 32596-605 Teckchandani AM, Panetti TS, Tsygankov AY (2005) Exp Cell Res 307, 247-58 Clonality: Polyclonal Isotype: IgG Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CBL Research Areas: Epigenetics and Nuclear Signaling;Cancer;Cell biology;Signal transduction