Phospho-FOXO4 (Ser197) Antibody

Size : 100 µL Clone Number: Aliases: AFX antibody; AFX1 antibody; Afxh antibody; ALL1-fused gene from X chromosome antibody; Fork head domain transcription factor AFX1 antibody; Forkhead box O4 antibody; Forkhead box protein O4 antibody; FOXO 4 antibody; Foxo4 antibody; FOXO4_HUMAN antibody; MGC117660 antibody; MGC120490 antibody; Mixed lineage leukemia; translocated to; 7 antibody; MLLT7 antibody; Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog; Drosophila); translocated to; 7 antibody; Myeloid/lymphoid or mixed lineage leukemia; translocated to; 7 antibody; RGD1561201 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P98177 Immunogen: Peptide sequence around phosphorylation site of serine 197 (A-A-S(p)-M-D) derived from Human AFX. Host: Rabbit Reactivity: Human, Mouse, Rat Tested Applications: ELISA, WB, IHC, IF; WB: 1: 500-1: 1000, IHC: 1: 50-1: 100, IF: 1: 100-1: 200 Background: Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Di Maira G, et al. (2005)Cell Death Differ; 12(6): 668-77. Essers MA, et al. EMBO J 2004 Nov. 11. Brownawell AM, (2001) Mol Cell Biol; 21(10): 3534-46. Kops GJ, et al. (1999) Nature; 398(6728): 630-4. Clonality: Polyclonal Isotype: IgG Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjugate: Non-conjugated Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: FOXO4 Research Areas: Epigenetics and Nuclear Signaling