Phospho-GAB1 (Tyr627) Antibody

Size : 100 µL Clone Number: Aliases: Gab 1 antibody; GAB1 antibody; GAB1_HUMAN antibody; GRB 2 associated binder 1 antibody; GRB 2 associated binding protein 1 antibody; GRB2 associated binding protein 1 isoform a antibody; GRB2 associated binding protein 1 isoform b antibody; GRB2-associated binder 1 antibody; GRB2-associated-binding protein 1 antibody; Growth factor receptor bound protein 2-associated protein 1 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q13480 Immunogen: Peptide sequence around phosphorylation site of tyrosine 627 (V-E-Y(p)-L-D) derived from Human Gab1. Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, WB, IF; WB: 1: 500-1: 1000, IF: 1: 100-1: 200 Background: The protein encoded by Gab1 is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Anders Kallin, et al. (2004) J. Biol. Chem ; 279: 17897 - 17904. Hideto Kameda, et al. (2001) Cell Growth Differ ; 12: 307. Masaki Osawa, et al. (2002) J. Cell Biol ; 158: 773. Clonality: Polyclonal Isotype: IgG Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjugate: Non-conjugated Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: GAB1 Research Areas: Cancer;Cell biology;Signal transduction