Phospho-G3BP1 (Ser232) Antibody

Size : 100 µL Clone Number: Aliases: ATP dependent DNA helicase VIII antibody; ATP-dependent DNA helicase VIII antibody; G3BP antibody; G3BP stress granule assembly factor 1 antibody; G3BP-1 antibody; G3bp1 antibody; G3BP1_HUMAN antibody; GAP binding protein antibody; GAP SH3 domain binding protein 1 antibody; GAP SH3 domain-binding protein 1 antibody; GTPase activating protein (SH3 domain) binding protein 1 antibody; hDH VIII antibody; Human DNA helicase VIII antibody; MGC111040 antibody; Ras GTPase activating protein binding protein 1 antibody; Ras GTPase activating protein SH3 domain binding protein antibody; Ras GTPase-activating protein-binding protein 1 antibody; RasGAP associated endoribonuclease G3BP antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q13283 Immunogen: Peptide sequence around phosphorylation site of serine 232 (S-S-S(p)-P-A) derived from Human G3BP-1. Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB, IHC, IF; WB: 1: 500-1: 1000, IHC: 1: 50-1: 100, IF: 1: 100-1: 200 Background: May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. Tao WA, et al. (2005) Nat Methods. 2(8): 591-598. Zheng H, et al. (2005) Mol Cell Proteomics. 4(6): 721-730. Beausoleil SA, et al. (2004) Proc Natl Acad Sci U S A.101 (33): 12130-12135. Tourrihre H, et al. (2003) J Cell Biol.160 (6): 823-831. Clonality: Polyclonal Isotype: IgG Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjugate: Non-conjugated Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: G3BP1 Research Areas: Epigenetics and Nuclear Signaling