Phospho-BLK (Tyr501) Antibody

Size : 100 µL Clone Number: Aliases: B lymphocyte kinase antibody; B lymphoid tyrosine kinase antibody; Blk antibody; BLK nonreceptor tyrosine kinase antibody; BLK_HUMAN antibody; EC 2.7.10.2 antibody; MGC 10442 antibody; MGC10442 antibody; MODY 11 antibody; MODY11 antibody; P55 BLK antibody; p55-BLK antibody; Tyrosine kinase B lymphocyte specific antibody; Tyrosine protein kinase antibody; Tyrosine-protein kinase BLK antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P51451 Immunogen: Peptide sequence around phosphorylation site of tyrosine 501 (R-Q-Y(p)-E-L) derived from Human BLK. Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, IHC; IHC: 1: 50-1: 100 Background: Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Islam K.B., J. Immunol. 154: 1265-1272(1995). Drebin J.A.,Oncogene 10: 477-486(1995). Greenman C.,Nature 446: 153-158(2007). Clonality: Polyclonal Isotype: IgG Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: BLK Research Areas: Cell biology