Phospho-IGF2R (Ser2409) Antibody

Size : 100 µL Clone Number: Aliases: 300 kDa mannose 6 phosphate receptor antibody; 300 kDa mannose 6-phosphate receptor antibody; Cation independent mannose 6 phosphate receptor antibody; Cation-independent mannose-6-phosphate receptor antibody; CD222 antibody; CD222 antigen antibody; CI Man 6 P receptor antibody; CI Man-6-P receptor antibody; CI MPR antibody; CI-M6PR antibody; CI-MPR antibody; CIMPR antibody; IGF 2 receptor antibody; IGF 2R antibody; IGF II receptor antibody; IGF-II receptor antibody; IGF2 receptor antibody; Igf2r antibody; Insulin like growth factor 2 receptor antibody; Insulin like growth factor II receptor antibody; Insulin-like growth factor 2 receptor antibody; Insulin-like growth factor II receptor antibody; M6P R antibody; M6P/IGF2 receptor antibody; M6P/IGF2R antibody; M6PR antibody; mannose 6 phosphate receptor antibody; mannose 6 phosphate receptor, cation independent antibody; MPR 300 antibody; MPR300 antibody; MPRI antibody; MPRI_HUMAN antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P11717 Immunogen: Peptide sequence around phosphorylation site of Serine 2409(Q-D-S(p)-E-D) derived from Human IGF2R. Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, WB, IHC; WB: 1: 500-1: 1000, IHC: 1: 50-1: 100 Background: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Morgan D.O., Nature 329: 301-307(1987). Oshima A., J. Biol. Chem. 263: 2553-2562(1988). Killian J.K., Mamm. Genome 10: 74-77(1999) Clonality: Polyclonal Isotype: IgG Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: IGF2R Research Areas: Tags & Cell Markers?Immunology;Signal transduction