Phospho-EIF2S1 (S51) Antibody

Size : 50 µL Clone Number: 1C6 Aliases: Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, EIF2S1, EIF2A Product Type: Recombinant Antibody Immunogen Species: Human UniProt ID: P05198 Immunogen: A synthesized peptide derived from human Phospho-EIF2S1 (S51) Host: Reactivity: Human Tested Applications: ELISA, WB, IHC, IF; Recommended dilution: WB: 1: 500-1: 5000, IHC: 1: 50-1: 200, IF: 1: 20-1: 200 Background: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. Clonality: Monoclonal Isotype: Rabbit IgG Purification Method: Affinity-chromatography Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: EIF2S1 Research Areas: Epigenetics and Nuclear Signaling