Phospho-ERN1 (S724) Antibody

Size : 50 µL Clone Number: 1F12 Aliases: Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, hIRE1p, Ire1-alpha, IRE1a, Serine/threonine-protein kinase, Endoribonuclease, ERN1 Product Type: Recombinant Antibody Immunogen Species: Human UniProt ID: O75460 Immunogen: A synthesized peptide derived from human Phospho-ERN1 (S724) Host: Reactivity: Human Tested Applications: ELISA, WB, IF; Recommended dilution: WB: 1: 500-1: 5000, IF: 1: 20-1: 200 Background: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation (PubMed: 9637683, PubMed: 11175748, PubMed: 12637535). The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis (PubMed: 24508390). Clonality: Monoclonal Isotype: Rabbit IgG Purification Method: Affinity-chromatography Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: ERN1 Research Areas: Signal Transduction