Phospho-FOXO3 (S253) Antibody

Size : 50 µL Clone Number: 1E1 Aliases: Forkhead box protein O3, AF6q21 protein, FOXO3 Product Type: Recombinant Antibody Immunogen Species: Human UniProt ID: O43524 Immunogen: A synthesized peptide derived from human Phospho-FOXO3 (S253) Host: Reactivity: Human Tested Applications: ELISA, WB, IHC; Recommended dilution: WB: 1: 500-1: 5000, IHC: 1: 50-1: 200 Background: Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. Clonality: Monoclonal Isotype: Rabbit IgG Purification Method: Affinity-chromatography Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: FOXO3 Research Areas: Epigenetics and Nuclear Signaling