Phospho-Histone H2AX (S139) Antibody

Size : 50 µL Clone Number: 1F10 Aliases: Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX Product Type: Recombinant Antibody Immunogen Species: Human UniProt ID: P16104 Immunogen: A synthesized peptide Host: Reactivity: Human Tested Applications: ELISA, WB; Recommended dilution: WB: 1: 3000-1: 10000 Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. Clonality: Monoclonal Isotype: Rabbit IgG Purification Method: Affinity-chromatography Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: H2AFX Research Areas: Epigenetics and Nuclear Signaling