ALCAM Antibody

Size : 50 µL Clone Number: 21B9 Aliases: CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166), ALCAM, MEMD Product Type: Recombinant Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q13740 Immunogen: A synthesized peptide derived from human ALCAM Host: Reactivity: Human, Mouse Tested Applications: ELISA, WB, IHC; Recommended dilution: WB: 1: 500-1: 2000, IHC: 1: 50-1: 200 Background: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed: 7760007, PubMed: 15496415, PubMed: 15048703, PubMed: 16352806, PubMed: 23169771, PubMed: 24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed: 15048703, PubMed: 16352806, PubMed: 24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed: 15294938, PubMed: 16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed: 15496415, PubMed: 16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed: 24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed: 23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed: 15496415, PubMed: 23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). {ECO: 0000250|UniProtKB: P42292, ECO: 0000269|PubMed: 15048703, ECO: 0000269|PubMed: 15294938, ECO: 0000269|PubMed: 15496415, ECO: 0000269|PubMed: 16352806, ECO: 0000269|PubMed: 24945728, ECO: 0000269|PubMed: 7760007}.; [Isoform 3]: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation. {ECO: 0000269|PubMed: 15496415}. Clonality: Monoclonal Isotype: Rabbit IgG Purification Method: Affinity-chromatography Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: ALCAM Research Areas: Tags & Cell Markers; Immunology