Alpha-2-macroglobulin antibody

Volume: 100 µg Purification: Protein A+G purification Form: liquid Purity: 95% as determined by SDS-PAGE Host: Mouse Clonality: monoclonal Clone ID: 6D0 Isotype: IgG2a Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Alpha-2-macroglobulin, also known as ?2-macroglobulin(?2M or A2M), is a protein abundant in the plasma of vertebrates and several invertebrates. A2M is an evolutionarily conserved arm of the innate immune system. It also mediates the proliferation of T cells and macrophages. A2M acts as a nonspecific protease inhibitor involved in the host defense mechanism that inactivates both endogenous and exogenous proteases, including trypsin, thrombin and collagenase. Even though A2M is produced predominantly by the liver, it may also be expressed in the reproductive tract, heart, and brain, and may have important roles in many physiological processes and medical illnesses including Alzheimer’s disease. Immunogen: alpha-2-macroglobulin Synonyms: A2M, Alpha 2 M, alpha 2 macroglobulin, CPAMD5, DKFZp779B086, FWP007, S863 7, ?-2M Observed MW: 185 kDa Uniprot ID: P01023 Reactivity: Human Tested Application: ELISA, IHC, WB Recommended dilution: WB: 1: 500-1: 2000; IP: 1: 500-1: 1000; IF: 1: 50-1: 500; IHC: 1: 20-1: 200 Gene ID: 2 Research Area: Immunology, Cardiovascular, Metabolism, Signal Transduction