ARHGEF5 antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Guanine nucleotide exchange factor which activates Rho GTPases(PubMed: 15601624). Strongly activates RHOA(PubMed: 15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1(By similarity). Involved in regulation of cell shape and actin cytoskeletal organization(PubMed: 15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia(PubMed: 14662653). Required for SRC-induced podosome formation(By similarity). Involved in positive regulation of immature dendritic cell migration(By similarity). Immunogen: Rho guanine nucleotide exchange factor(GEF) 5 Synonyms: TIM Observed MW: 60 kDa Uniprot ID: Q12774 Reactivity: Human, Mouse, Rat Tested Application: ELISA, WB, IHC, IP Recommended dilution: WB: 1: 500-1: 2000; IP: 1: 200-1: 1000; IHC: 1: 20-1: 200 Gene ID: 7984 Research Area: Signal Transduction